Updated: June 22, 2024

During its three season run, many actors made guest appearances, including familiar actors and / or actors who went on to become well known. Among those appearing in Lost In Space episodes:

Joe E. Tata, Alan Hewitt, Francine York, Don Matheson, Kurt Russell, Ford Rainey, Warren Oates, Norman Levitt, Tommy Farrell, Lew Wagner, Lyle Waggoner, Albert Salmi, Royal Dano, Strother Martin, Michael J Pollard, Byron Morrow, Arte Johnson, Fritz Feld, Lew Gello, John Carradine, Al Lewis, Hans Conried, Dennis Patrick, Michael Rennie among many others. Future Hill Street Blues stars, Daniel J. Travanti ( billed as "Danny Travanty" ) and Michael Conrad, made guest appearances on separate episodes. While Mark Goddard was playing Major. West, he had a guest-appearance as well. Jonathan Harris, although a permanent cast member, was listed in the opening credits as "Special Guest Star" of every episode of Lost in Space.