Updated: February 02, 2018

A submarine design very similar to the craft on the 1961 cover, and its mission to save the world, shows up in a Dell Comics series called Voyage to the Deep in 1962 to capitalize on the movie's popularity. Its mission also took it to the Mariana Trench to stop the Earth from wobbling out of orbit. It stopped publishing by issue #4. That ship was named Proteus, later the name of the 'submarine' in Fantastic Voyage.

In 1961 Dell Comics created a full color adaptation of the Voyage to the Bottom of the Sea movie. The comic was Four Color Comics #1230 and drawn by Sam Glanzman. It has a few publicity stills of the movie plus a section on the history of submarines. In the comic book the Admiral's first name is Farragut instead of Harriman. There was also a Voyage to the Bottom of the Sea coloring book released in the mid-1960's.

MAD Magazine published a parody based on the TV series in one of their monthly issues entitled, "Voyage to See What's on the Bottom".